uncouplers of oxidative phosphorylationAugust 12, 2021
Uncouplers of oxidative phosphorylation in mitochondria inhibit the coupling between the electron transport and phosphorylation reactions and thus inhibit ATP synthesis without affecting the respiratory chain and ATP synthase.
In the presence of an uncoupling agent, energy released via the ETC is converted into heat.
This mechanism is used by hibernating animals to stay warm in the winter, since they don’t need ATP for anabolic processes while they are resting.
Examples of uncouplers: Natural: Thermogenin or uncoupling protein (UCP). Synthetic: 2,4,-dinitrophenol.